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Trimegestone-13C, d3

CAT: 0804-HY-106827S1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-106827S1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Trimegestone-13C, d3 is 13C and deuterated labeled Trimegestone. Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC50 value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC50=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes[1][2].
Product Name Alternative
RU 27987-13C, d3
UNSPSC
12352211
Target
Androgen Receptor; Isotope-Labeled Compounds; Phosphatase; Progesterone Receptor
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@](CC[C@]2(C)C([C@@H](O)[13C]([2H])([2H])[2H])=O)([H])[C@@]3([H])C(CC1)=C4C(CC3)=CC(CC4)=O
Molecular Formula
C21 13CH27D3O3
Molecular Weight
346.48
References & Citations
[1]Wahab M, et al. Trimegestone: expanding therapeutic choices for the treatment of the menopause. Expert Opin Investig Drugs. 2001 Sep;10 (9) :1737-44. |[2]Zhang Z, et al. In vitro characterization of trimegestone: a new potent and selective progestin. Steroids. 2000 Oct-Nov;65 (10-11) :637-43. |[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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