(E/Z) -Mirin

• Description:

  (E/Z) -Mirin is a mixture of (E) -Mirin and Mirin ((Z) -Mirin) (HY-19959) configurations. Among them, Mirin is an inhibitor of MRN (Mre11-Rad50-Nbs1) . Mirin prevents MRN-dependent ATM activation without affecting ATM protein kinase activity[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  ATM/ATR

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mirin-1.html

• Concentration:

  10mM

• Purity:

  99.22

• Solubility:

  DMSO : 83.33 mg/mL (ultrasonic)

• Smiles:

  O=C1N=C(N)S/C1=C/C2=CC=C(O)C=C2

• Molecular Formula:

  C10H8N2O2S

• Molecular Weight:

  220.25

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Dupré A, et al. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol. 2008;4 (2) :119-125.|[2]Ying S, et al. Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1. Cancer Res. 2012;72 (11) :2814-2821.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  299953-00-7