SMI-4a

• UNSPSC Description:

  SMI-4a (TCS-PIM-1-4a) is a poten, selective, cell-permeable and ATP-competitive Pim-1 inhibitor with an IC50 of 24 μM and a Ki of 0.6 μM. SMI-4a also inhibits Pim-2 (IC50 of 100 μM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. SMI-4a has anticancer activity[1].

• Target Antigen:

  Pim

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/_Z_-SMI-4a.html

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C(NC/1=O)SC1=C/C2=CC=CC(C(F)(F)F)=C2

• Molecular Weight:

  273.23

• References & Citations:

  [1]Xia Z, et al. Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J Med Chem. 2009 Jan 8;52(1):74-86.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  438190-29-5