SMI-10B13

• Description:

  SMI-10B13 is an Oncostatin M (OSM) inhibitor with a KD of 6.6 μM. SMI-10B13 inhibits OSM-mediated STAT3 phosphorylation in T47D and MCF-7 cell lines (IC50 = 136 and 164 nM, respectively) . SMI-10B13 shows anti-tumor effect in human breast cancer mice models[1].

• UNSPSC:

  12352005

• Target:

  Interleukin Related; STAT

• Related Pathways:

  Immunology/Inflammation; JAK/STAT Signaling; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Smiles:

  O=C (/C=C/C1=CC (C2=CC3=C (C=C2) C=CN3) =C (O1) C4=CC=C5C=CNC5=C4) O

• Molecular Formula:

  C23H16N2O3

• Molecular Weight:

  368.38

• References & Citations:

  [1]Wolf CL, et al. Development of the First Small-Molecule Inhibitor Targeting Oncostatin M for Treatment of Breast Cancer. J Med Chem. 2025 Aug 14;68 (15) :15422-15445.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2502294-68-8