SMI-10B13

CAT: 0804-HY-175465-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-175465-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
SMI-10B13 is an Oncostatin M (OSM) inhibitor with a KD of 6.6 μM. SMI-10B13 inhibits OSM-mediated STAT3 phosphorylation in T47D and MCF-7 cell lines (IC50 = 136 and 164 nM, respectively) . SMI-10B13 shows anti-tumor effect in human breast cancer mice models[1].
CAS Number
[2502294-68-8]
UNSPSC
12352005
Target
Interleukin Related; STAT
Related Pathways
Immunology/Inflammation; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(/C=C/C1=CC(C2=CC3=C(C=C2)C=CN3)=C(O1)C4=CC=C5C=CNC5=C4)O
Molecular Formula
C23H16N2O3
Molecular Weight
368.38
References & Citations
[1]Wolf CL, et al. Development of the First Small-Molecule Inhibitor Targeting Oncostatin M for Treatment of Breast Cancer. J Med Chem. 2025 Aug 14;68 (15) :15422-15445.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-125025-01SMI 6860766
HY-16576A-01SMI-4a
HY-101947-01SMI-16a
HY-170817SMI-1074
HY-148692-01OSM-SMI-10B
HY-148693OSM-SMI-8
HY-148693A(E/Z) -OSM-SMI-8
HY-148692A(E/Z) -OSM-SMI-10B
HY-114376Borocaptate-10B12 (sodium)
HY-176360SO-Barenylacetic acid-10B10

Alternative Products

CatalogName
MF-0119416-01SMI-10B13
MBS3608419-01SMI-4a
MBS3607544-01SMI-16a
MBS132383-01SMI-4q
MBS5774552SMI-6860766
466182-01SMI-481

Popular Products