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BMS-P5 (free base)

CAT: 0804-HY-137655A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-137655A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMS-P5 free base is a selective and orally active peptidylarginine deiminase 4 (PAD4) inhibitor with an IC50 of 98 nM. BMS-P5 free base shows selective for PAD4 over PAD1, PAD2, and PAD3. BMS-P5 free base blocks multiple myeloma (MM) -induced neutrophil extracellular trap (NET) formation and delays progression of MM in a syngeneic mouse model[1].
CAS Number
1550371-22-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Protein Arginine Deiminase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bms-p5-free-base.html
Purity
99.93
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(N1[C@@H](C)CC[C@@H](N)C1)C2=CC(OC)=C3C(N=C(C4=CC5=CC=CN=C5N4CC6CC6)N3C)=C2
Molecular Formula
C27H32N6O2
Molecular Weight
472.58
Precautions
H302, H315, H319
References & Citations
[1]Marina Li, et al. A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma. Mol Cancer Ther. 2020 Jul;19 (7) :1530-1538.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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