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JT21-25

CAT: 0804-HY-161283Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161283Size:1 Each
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Description
JT21-25 (compound 9h) is a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with IC50 of 5.1 nM[1].
CAS Number
2996864-57-2
UNSPSC
12352005
Target
MAP3K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/jt21-25.html
Solubility
10 mM in DMSO
Smiles
BrC1=CC=CC2=C1N=C(C(NC3=NC(C4=NN=CN4C(C)C)=CC=C3)=O)C=C2
Molecular Formula
C20H17BrN6O
Molecular Weight
437.29
References & Citations
[1]Lidan Pang, et al. Discovery of a quinoline-containing compound JT21-25 as a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1) . Bioorg Chem. 2024 Mar:144:107167.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP3K5/ASK1

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