Dovitinib lactate 500mg

CAT: 0628-A21851-500Size: 500 mgDry Ice: NoHazardous: No

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CAT#:0628-A21851-500Size:500 mg

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CAS Number

692737-80-7

Chemical Information

dovitinib lactate anhydrous

Dovitinib Lactate is the orally bioavailable lactate salt of a benzimidazole-quinolinone compound with potential antineoplastic activity. Dovitinib strongly binds to fibroblast growth factor receptor 3 (FGFR3) and inhibits its phosphorylation, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell death. In addition, this agent may inhibit other members of the RTK superfamily, including the vascular endothelial growth factor receptor; fibroblast growth factor receptor 1; platelet-derived growth factor receptor type 3; FMS-like tyrosine kinase 3; stem cell factor receptor (c-KIT); and colony-stimulating factor receptor 1; this may result in an additional reduction in cellular proliferation and angiogenesis, and the induction of tumor cell apoptosis. The activation of FGFR3 is associated with cell proliferation and survival in certain cancer cell types.

CAS Number	692737-80-7
PubChem CID	135431668
IUPAC Name	4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one;2-hydroxypropanoic acid
Molecular Formula	C24H27FN6O4
Molecular Weight	482.5
Topological Polar Surface Area	148
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	3
Heavy Atom Count	35
Formal Charge	0
Complexity	737

SMILES

CC(C(=O)O)O.CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=C(C5=C(C=CC=C5F)NC4=O)N

InChI

InChI=1S/C21H21FN6O.C3H6O3/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29;1-2(4)3(5)6/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29);2,4H,1H3,(H,5,6)

InChIKey

ZRHDKBOBHHFLBW-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 692737-80-7

CID: 135431668

Formula: C24H27FN6O4

MW: 482.5

Interactive 3D Structure

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Computed Properties

Property	Value
Molecular Weight	482.5
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	3
Exact Mass	482.20778153
Monoisotopic Mass	482.20778153
Topological Polar Surface Area	148 Å²
Heavy Atom Count	35
Formal Charge	0
Complexity	737
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	2
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
T7104-01	Dovitinib lactate
HY-10207-01	Dovitinib (lactate)
HY-10207R-01	Dovitinib (lactate) (Standard)
MBS5784821-01	Dovitinib (TKI258) Lactate
M19259-01	Dovitinib lactate hydrate
HY-B0062	Dovitinib (lactate hydrate)
BIFK0016	Dovitinib Lactate Salt

Dovitinib lactate 500mg

Chemical Information

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