Dovitinib (lactate hydrate)

Dovitinib (lactate hydrate)

• CAS Number: 915769-50-5
• UNSPSC Description: Dovitinib lactate hydrate (TKI258 lactate hydrate) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively[1].
• Target Antigen: c-Kit; FGFR; FLT3; PDGFR; VEGFR
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/dovitinib-lactate-hydrate.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1NC2=C(C(F)=CC=C2)C(N)=C1C3=NC4=CC=C(N5CCN(C)CC5)C=C4N3.CC(O)C(O)=O.[H]O[H]
• Molecular Weight: 500.52
• References & Citations: [1]Trudel S, et al. CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma. Blood. 2005, 105(7), 2941-2948.
• Shipping Conditions: Room temperature
• Clinical Information: Phase 3