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Dovitinib (lactate) (Standard)

CAT: 0804-HY-10207R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10207R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dovitinib (lactate) (Standard) is the analytical standard of Dovitinib (lactate) . This product is intended for research and analytical applications. Dovitinib lactate (TKI258 lactate) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively[1].
CAS Number
692737-80-7
Product Name Alternative
CHIR-258 lactate (Standard) ; TKI-258 lactate (Standard)
UNSPSC
12352005
Target
C-Kit; FGFR; FLT3; PDGFR; Reference Standards; VEGFR
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(N1)C(C(NC2=C3)=NC2=CC=C3N4CCN(C)CC4)=C(N)C5=C1C=CC=C5F.O=C(O)C(C)O
Molecular Formula
C24H27FN6O4
Molecular Weight
482.51
References & Citations
[1]Trudel S, et al. CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t (4;14) multiple myeloma. Blood. 2005, 105 (7), 2941-2948.|[2]Huynh H, et al. Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma. J Hepatol. 2012, 56 (3), 595-601.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

dovitinib lactate anhydrous

Dovitinib Lactate is the orally bioavailable lactate salt of a benzimidazole-quinolinone compound with potential antineoplastic activity. Dovitinib strongly binds to fibroblast growth factor receptor 3 (FGFR3) and inhibits its phosphorylation, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell death. In addition, this agent may inhibit other members of the RTK superfamily, including the vascular endothelial growth factor receptor; fibroblast growth factor receptor 1; platelet-derived growth factor receptor type 3; FMS-like tyrosine kinase 3; stem cell factor receptor (c-KIT); and colony-stimulating factor receptor 1; this may result in an additional reduction in cellular proliferation and angiogenesis, and the induction of tumor cell apoptosis. The activation of FGFR3 is associated with cell proliferation and survival in certain cancer cell types.

CAS Number692737-80-7
PubChem CID135431668
IUPAC Name4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one;2-hydroxypropanoic acid
Molecular FormulaC24H27FN6O4
Molecular Weight482.5
Topological Polar Surface Area148
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count9
Rotatable Bond Count3
Heavy Atom Count35
Formal Charge0
Complexity737
SMILES
CC(C(=O)O)O.CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=C(C5=C(C=CC=C5F)NC4=O)N
InChI
InChI=1S/C21H21FN6O.C3H6O3/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29;1-2(4)3(5)6/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29);2,4H,1H3,(H,5,6)
InChIKey
ZRHDKBOBHHFLBW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of dovitinib lactate anhydrous
CAS: 692737-80-7
CID: 135431668
Formula: C24H27FN6O4
MW: 482.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight482.5
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count9
Rotatable Bond Count3
Exact Mass482.20778153
Monoisotopic Mass482.20778153
Topological Polar Surface Area148 Ų
Heavy Atom Count35
Formal Charge0
Complexity737
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
T7104-01Dovitinib lactate
MBS5784821-01Dovitinib (TKI258) Lactate
A21851-500Dovitinib lactate 500mg
A21851-100Dovitinib lactate 100mg
A21851-50Dovitinib lactate 50mg
M19259-01Dovitinib lactate hydrate
A21851-200Dovitinib lactate 200mg
A21851-5Dovitinib lactate 5mg

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