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Dovitinib (lactate)

CAT: 0804-HY-10207-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10207-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dovitinib lactate (TKI258 lactate) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively[1].
CAS Number
692737-80-7
Product Name Alternative
CHIR-258 lactate; TKI-258 lactate
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
C-Kit; FGFR; FLT3; PDGFR; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Dovitinib-lactate.html
Purity
99.75
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(N1)C(C(NC2=C3)=NC2=CC=C3N4CCN(C)CC4)=C(N)C5=C1C=CC=C5F.O=C(O)C(C)O
Molecular Formula
C24H27FN6O4
Molecular Weight
482.51
Precautions
H302, H315, H319, H335
References & Citations
[1]Trudel S, et al. CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t (4;14) multiple myeloma. Blood. 2005, 105 (7), 2941-2948.|[2]Huynh H, et al. Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma. J Hepatol. 2012, 56 (3), 595-601.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
PDGFRα; PDGFRβ; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4
Citation 01
Nat Commun. 2025 Jul 24;16 (1) :6777.|Biochemistry for Health, NOVA University of Lisbon. 2019 Jul.|bioRxiv. 2024 June 09.|Front Cell Dev Biol. 2020 May 7:8:287.|Harvard Medical School LINCS LIBRARY|J Biol Chem. 2023 Apr;299 (4) :104595|NPJ Precis Oncol. 2021 Jul 16;5 (1) :66.|Sci Transl Med. 2018 Jul 18;10 (450) :eaaq1093.|Theranostics. 2018 Jul 30;8 (15) :4262-4278.|University of Düsseldorf. 2024.

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Alternative Products

CatalogName
T7104-01Dovitinib lactate
MBS5784821-01Dovitinib (TKI258) Lactate
A21851-500Dovitinib lactate 500mg
A21851-100Dovitinib lactate 100mg
A21851-50Dovitinib lactate 50mg
M19259-01Dovitinib lactate hydrate
A21851-200Dovitinib lactate 200mg
A21851-5Dovitinib lactate 5mg

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