NICE-01

• Target:

  Others|||Epigenetic Reader Domain

• Related Pathways:

  Chromatin/Epigenetic|||Others

• Bioactivity:

  NICE-01 (AP1867-PEG2-JQ1; AP-PEG2-JQ1) is a bifunctional compound that facilitates the nuclear import of cytosolic cargoes by utilizing the nuclear-localized bromodomain-containing protein 4 (BRD4) as a carrier for co-import and subsequent nuclear entrapment [1].

• Smiles:

  CC=1C2=C(N3C([C@H](CC(NCCOCCOCCNC(COC4=CC([C@H](OC(=O)[C@H]5N(C([C@@H](CC)C6=CC(OC)=C(OC)C(OC)=C6)=O)CCCC5)CCC7=CC(OC)=C(OC)C=C7)=CC=C4)=O)=O)N=C2C8=CC=C(Cl)C=C8)=NN=C3C)SC1C

• Molecular Formula:

  C63H76ClN7O13S

• Molecular Weight:

  1206.84

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2982819-94-1