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Aftin-5

CAT: 0804-HY-136674-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-136674-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aftin-5 is an inducer for Amyloid-β 42 (Aβ42) . Aftin-5 upregulates Aβ42 and downregulates Aβ38 levels in a β-secretase- and γ-secretase-dependent manner by altering the ultrastructure of mitochondria. Aftin-5 exhibits slightly cytotoxicity in cell SH-SY5Y, HT22, N2a and N2a-AβPP695, with IC50s of 180, 194, 178 and 150 μM, respectively[1].
CAS Number
1461717-05-4
UNSPSC
12352005
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aftin-5.html
Purity
99.70
Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC[C@H](CO)NC1=NC(N(C2=CC=CC=C2)C)=C3N=CN(C3=N1)C(C)C
Molecular Formula
C19H26N6O
Molecular Weight
354.45
References & Citations
[1]Hochard A, et al., Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease? J Alzheimers Dis. 2013;35 (1) :107-20.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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