BOT-64

• UNSPSC Description:

  BOT-64 is an inhibitory κB (IκB) kinase β (IKKβ) inhibitor with an IC50 of 1 μM. BOT-64 blocks lipopolysaccharide-induced nuclear factor-κB activation and nuclear factor-κB-regulated inflammatory gene transcription[1].

• Target Antigen:

  IKK

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/bot-64.html

• Smiles:

  O=C1CC(C)(C)CC2=C1S/C(O2)=N\C3=CC=CC=C3

• Molecular Weight:

  273.35

• References & Citations:

  [1]Kim BH, et al. Benzoxathiole derivative blocks lipopolysaccharide-induced nuclear factor-kappaB activation and nuclear factor-kappaB-regulated gene transcription through inactivating inhibitory kappaB kinase beta. Mol Pharmacol. 2008 Apr;73(4):1309-18.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  113760-29-5