MN-64

• Description:

  MN-64 is a potent tankyrase 1 inhibitor, with IC50s of 6 nM, 72 nM, 19.1 μM, and 39.4 μM for TNKS1, TNKS2, ARTD1 and ARTD2, respectively.

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  PARP

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/MN-64.html

• Purity:

  99.61

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1C=C(C2=CC=C(C(C)C)C=C2)OC3=CC=CC=C13

• Molecular Formula:

  C18H16O2

• Molecular Weight:

  264.32

• Precautions:

  H301

• References & Citations:

  [1]Narwal M, et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013 Oct 24;56 (20) :7880-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PARP1; PARP2; TNKS1/PARP5A; TNKS2/PARP5B

• CAS Number:

  [92831-11-3]