MN-64

• Description :

  MN-64 is a potent tankyrase 1 inhibitor, with IC50s of 6 nM, 72 nM, 19.1 μM, and 39.4 μM for TNKS1, TNKS2, ARTD1 and ARTD2, respectively.

• UNSPSC :

  12352005

• Hazard Statement :

  H301

• Target :

  PARP

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/MN-64.html

• Purity :

  99.61

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1C=C(C2=CC=C(C(C)C)C=C2)OC3=CC=CC=C13

• Molecular Formula :

  C18H16O2

• Molecular Weight :

  264.32

• Precautions :

  H301

• References & Citations :

  [1]Narwal M, et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013 Oct 24;56 (20) :7880-9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PARP1; PARP2; TNKS1/PARP5A; TNKS2/PARP5B

• CAS Number :

  [92831-11-3]