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Fludarabine (phosphate)

CAT: 0804-HY-B0028-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0028-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fludarabine (phosphate) is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.
CAS Number
75607-67-9
Product Name Alternative
NSC 118218 (phosphate)
UNSPSC
12352005
Hazard Statement
H341, H361
Target
Apoptosis; Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Fludarabine-phosphate.html
Purity
99.77
Solubility
DMSO : ≥ 100 mg/mL|H2O : 5 mg/mL (ultrasonic)
Smiles
NC1=C2C(N([C@H]3[C@@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O3)C=N2)=NC(F)=N1
Molecular Formula
C10H13FN5O7P
Molecular Weight
365.21
Precautions
H341, H361
References & Citations
[1]Sorscher EJ, et al. In vivo antitumor activity of intratumoral fludarabine phosphate in refractory tumors expressing E. coli purine nucleoside phosphorylase. Cancer Chemother Pharmacol. 2012 Aug;70 (2) :321-9.|[2]Kikuchi E, et al. Delivery of replication-competent retrovirus expressing Escherichia coli purine nucleoside phosphorylase increases the metabolism of the prodrug, fludarabine phosphate and suppresses the growth of bladder tumor xenografts. Cancer Gene Th
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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