Histamine (phosphate)

• Description:

  Histamine phosphate is the agonist for histamine receptor and a vasodilator. Histamine phosphate is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine phosphate affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine phosphate can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma[1][2][3][4][5][6][7].

• Product Name Alternative:

  Histamine diphosphate

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H317, H318, H334, H335

• Target:

  Akt; Apoptosis; Endogenous Metabolite; Histamine Receptor; p38 MAPK; Reactive Oxygen Species (ROS)

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; PI3K/Akt/mTOR

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Endocrinology; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Histamine-phosphate.html

• Purity:

  99.34

• Solubility:

  DMSO : 1.43 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

• Smiles:

  NCCC1=CNC=N1.O=P (O) (O) O.O=P (O) (O) O

• Molecular Formula:

  C5H15N3O8P2

• Molecular Weight:

  307.14

• Precautions:

  H302, H315, H317, H318, H334, H335

• References & Citations:

  [1]Okabe S, et al. Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers. Am J Dig Dis. 1977 Aug;22 (8) :677-84. |[2]Rietveld S et al. The influence of respiratory sounds on breathlessness in children with asthma: a symptom-perceptionapproach. Health Psychol. 1997 Nov;16 (6) :547-53. |[3]Malmberg-Aiello P, et al., Role of histamine in rodent antinociception. Br J Pharmacol. 1994 Apr;111 (4) :1269-79. |[4]Medina V, et al., Histamine-mediated signaling processes in human malignant mammary cells. Cancer Biol Ther. 2006 Nov;5 (11) :1462-71.|[5]Ferreira R, et al., Histamine modulates microglia function. J Neuroinflammation. 2012 May 8;9:90. |[6]MARTIN L. The effects of histamine on the vaginal epithelium of the mouse. J Endocrinol. 1962 Jan;23:329-40. |[7]Yang LP, et al. Spotlight on histamine dihydrochloride in acute myeloid leukaemia. Drugs Aging. 2011 Apr 1;28 (4) :325-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Citation 01:

  Insect Sci. 2025 Sep 11.|JID Innov. 2025 Apr 3;5 (4) :100369.|Adv Sci (Weinh) . 2023 Mar;10 (7) :e2203869.|Biochem Biophys Res Commun. 2025 Apr 1:755:151566.|Biol Pharm Bull. 2023;46 (6) :864-868.|bioRxiv. 2024 June 12.|Br J Pharmacol. 2021 Apr;178 (7) :1669-1683.|Cancer Cell. 2022 Oct 10;40 (10) :1111-1127.e9.|FASEB J. 2025 Jul 15;39 (13) :e70778.|Fishes. 2025 Aug 14.|Front Pharmacol. 2019 Nov 15;10:1380.|J Agric Food Chem. 2025 Nov 19;73 (46) :29604-29618.|J Cell Commun Signal. 2023 Mar;17 (1) :151-165.|Microbiol Spectr. 2023 Jan 31;11 (2) :e0469822.|Pharm Res. 2025 Aug;42 (8) :1315-1329.|Immunity. 2025 Aug 12:S1074-7613 (25) 00314-0.|mBio. 2022 Oct 26;13 (5) :e0200422.

• CAS Number:

  51-74-1