MP-A08

• Description :

  MP-A08 is a highly selective ATP competitive sphingosine kinase (SPHK1) inhibitor that targets both SphK1 and SphK2 with Ki values of 6.9 ± 0.8 μM and 27 ± 3 μM, respectively.

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319

• Target :

  SphK

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/MP-A08.html

• Purity :

  98.0

• Solubility :

  DMSO : ≥ 50 mg/mL

• Smiles :

  O=S(C1=CC=C(C)C=C1)(NC2=CC=CC=C2/C=N/C3=CC=CC=C3NS(=O)(C4=CC=C(C)C=C4)=O)=O

• Molecular Formula :

  C27H25N3O4S2

• Molecular Weight :

  519.64

• Precautions :

  H315, H319

• References & Citations :

  [1]Pitman MR et al. A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget, 2015 Mar 30, 6 (9) :7065-83.|[2]Dimasi DP et al. Examining the Role of Sphingosine Kinase-2 in the Regulation of Endothelial Cell Barrier Integrity. Microcirculation, 2016 Apr, 23 (3) :248-65.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  SphK1

• CAS Number :

  [219832-49-2]