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ERX-41

CAT: 0804-HY-148755-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-148755-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ERX-41 is an orally active and stereospecific small molecule targeting to lysosomal acid lipase A (LIPA) . ERX-41 induces endoplasmic reticulum (ER) stress resulting in cell death, indicating a function independent of LIPA but dependent on its ER localization. ERX-41 involves in a targeted strategy for solid tumors[1].
CAS Number
[2440087-54-5]
UNSPSC
12352005
Target
Lipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/erx-41.html
Purity
98.25
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(OCCO)=C(C=C1)[N+]([O-])=O)NC2=C(C=C(C=C2)C(NC3=C(C=C(C=C3)C(N[C@H]4CC[C@@H](CC4)C)=O)OCC(C)C)=O)OCC(C)C
Molecular Formula
C38H48N4O9
Molecular Weight
704.81
References & Citations
[1]Liu X, et al. Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress. Nat Cancer. 2022 Jul;3 (7) :866-884.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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