MS-553

• Description:

  MS-553 is a potent, ATP-competitive and reversible inhibitor of conventional PKC enzymes with Kis of 5.3 and 10.4 nM for human PKCβ and PKCα, and IC50s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM for PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε, respectively.

• UNSPSC:

  12352005

• Target:

  PKC

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; TGF-beta/Smad

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/PKC-IN-1.html

• Concentration:

  10mM

• Purity:

  99.79

• Solubility:

  DMSO : 200 mg/mL (ultrasonic)

• Smiles:

  O=C(N1[C@@H](C)CN(CC2CCOCC2)[C@H](C)C1)N(C3)C(C)(C)C4=C3C(NC5=NC(C)=NC=C5F)=NN4

• Molecular Formula:

  C25H37FN8O2

• Molecular Weight:

  500.61

• References & Citations:

  [1]Michael Niesman, et al. Treatment of autoimmune disease. WO2015179847A1.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PKCα; PKCβ; PKCγ; PKCε; PKCθ; PKCμ

• CAS Number:

  1046787-18-1