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ONX-0914 (TFA)

CAT: 0804-HY-13207A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13207A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ONX-0914 (PR-957) TFA is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 TFA blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 TFA is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (Ki=5.2 μM) . ONX-0914 TFA reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1[1][2][3].
Product Name Alternative
PR-957 (TFA)
UNSPSC
12352005
Target
Bacterial; HIV; Proteasome
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/onx-0914-tfa.html
Concentration
10mM
Purity
98.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](C)C(N[C@@H](CC1=CC=C(OC)C=C1)C(N[C@@H](CC2=CC=CC=C2)C([C@]3(C)OC3)=O)=O)=O)CN4CCOCC4.O=C(O)C(F)(F)F
Molecular Formula
C33H41F3N4O9
Molecular Weight
694.70
References & Citations
[1]Muchamuel T, et al. A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis [published correction appears in Nat Med. 2009 Nov;15 (11) :1333]. Nat Med. 2009;15 (7) :781-787.|[2]Rožman K, et al. Psoralen Derivatives as Inhibitors of Mycobacterium tuberculosis Proteasome. Molecules. 2020;25 (6) :1305. Published 2020 Mar 12.|[3]Lin J, et al. PR-957, a selective immunoproteasome inhibitor, reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1. Biochem Pharmacol. 2018;156:511-523.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1

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Alternative Products

CatalogName
MBS5816020ONX-0914 TFA
TRC-O658000-100MGONX 0914
M16857-01ONX-0914
A12653-50ONX-0914 50mg
A12653-5ONX-0914 5mg
A12653-100ONX-0914 100mg
A12653-10ONX-0914 10mg
A12653-1ONX-0914 1mg
A12653-25ONX-0914 25mg
MBS132461-01ONX-0914, PR-957

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