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ONX-0914

CAT: 0804-HY-13207-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13207-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ONX-0914 (PR-957) is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (Ki=5.2 μM) . ONX-0914 reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1[1][2][3].
CAS Number
960374-59-8
Product Name Alternative
PR-957
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; HIV; Proteasome
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ONX-0914.html
Purity
99.72
Solubility
DMSO : ≥ 35 mg/mL
Smiles
O=C(N[C@@H](C)C(N[C@@H](CC1=CC=C(OC)C=C1)C(N[C@@H](CC2=CC=CC=C2)C([C@]3(C)OC3)=O)=O)=O)CN4CCOCC4
Molecular Formula
C31H40N4O7
Molecular Weight
580.67
Precautions
H302, H315, H319, H335
References & Citations
[1]Muchamuel T, et al. A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis [published correction appears in Nat Med. 2009 Nov;15 (11) :1333]. Nat Med. 2009;15 (7) :781-787.|[2]Rožman K, et al. Psoralen Derivatives as Inhibitors of Mycobacterium tuberculosis Proteasome. Molecules. 2020;25 (6) :1305. Published 2020 Mar 12.|[3]Lin J, et al. PR-957, a selective immunoproteasome inhibitor, reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1. Biochem Pharmacol. 2018;156:511-523.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1

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