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HTH-01-091 (TFA)

CAT: 0804-HY-122665ASize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122665ASize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HTH-01-091 TFA is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM. HTH-01-091 TFA also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 TFA can be uesd for breast cancer research[1].
UNSPSC
12352005
Target
CDK; DYRK; GSK-3; MELK; mTOR; Pim; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hth-01-091-tfa.html
Purity
99.48
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N([C@H]2CC[C@H](CN(C)C)CC2)C3=C(CN1)C=NC4=CC=C(C5=CC(Cl)=C(O)C(Cl)=C5)C=C34.OC(C(F)(F)F)=O
Molecular Formula
C28H29Cl2F3N4O4
Molecular Weight
613.46
References & Citations
[1]Huang HT, et al. MELK is not necessary for the proliferation of basal-like breast cancer cells. Elife. 2017 Sep 19;6:e26693.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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