J-1063

• Description :

  J-1063 is a potent, selective and orally active ALK5 inhibitor with an IC50 of 0.039 μM. J-1063 shows anti-fibrotic effect by the inhibition of inflammatory infiltration, collagen deposition, and hepatocytes necrosis. J-1063 has the potential for the research of liver fibrosis[1].

• CAS Number :

  [2374772-46-8]

• UNSPSC :

  12352005

• Target :

  TGF-β Receptor

• Type :

  Reference compound

• Related Pathways :

  TGF-beta/Smad

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/j-1063.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC1=NC(C2=NN(C=C2C3=CC4=C(S3)C=CN=C4)CC(NC5=CC=CC=C5)=O)=CC=C1

• Molecular Formula :

  C24H19N5OS

• Molecular Weight :

  425.51

• References & Citations :

  [1]Zheng GH, et al. The in vitro and in vivo study of a pyrazole derivative, J-1063, as a novel anti-liver fibrosis agent: Synthesis, biological evaluation, and mechanistic analysis. Bioorg Chem. 2022; 122:105715.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ALK5