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MM-433593

CAT: 0804-HY-115004-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-115004-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MM-433593 is a potent and selective inhibitor of fatty acid amide hydrolase-1 (FAAH-1) that is orally administered to inhibit pain, inflammation, and related disorders. Pharmacokinetic studies of MM-433593 in macaques revealed a biphasic elimination profile with a rapid distribution phase and a slower elimination phase, with a systemic clearance of 8-11 mL/min/kg. MM-433593 exhibits moderate oral bioavailability (14-21%) and its metabolism primarily involves oxidation of the methyl group on the indole ring, resulting in a variety of sulfate, glucuronide, or glutathione-conjugated metabolites[1].
CAS Number
1006604-91-6
UNSPSC
12352005
Target
FAAH
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mm-433593.html
Smiles
COC1=CC(NC(C(C2=C(C)N(CC3=CC=C(Cl)C=C3)C4=CC=C(C)C=C24)=O)=O)=CC=N1
Molecular Formula
C25H22ClN3O3
Molecular Weight
447.91
References & Citations
[1]Banijamali AR, et al. Metabolism and disposition of MM-433593, a selective FAAH-1 inhibitor, in monkeys. Pharmacol Res Perspect. 2014 Oct;2 (5) :e00059.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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