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MM-206

CAT: 0804-HY-121725-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121725-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MM-206, a STAT3 activity inhibitor, potently inhibits the STAT3 SH2 domain-phosphopeptide interaction with IC50 of 1.2 μM. MM-206 demonstrates dose-dependent induction of apoptosis in acute myeloid leukemia (AML) cell lines[1].
CAS Number
1809581-87-0
UNSPSC
12352005
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mm-206.html
Purity
99.9
Solubility
DMF : 25 mg/mL (ultrasonic; warming)
Smiles
O=S(C1=C(C(F)=C(C(F)=C1F)F)F)(NC2=C3C=CC=CC3=C(C(SC4=CC=CC=C4)=C2)O)=O
Molecular Formula
C22H12F5NO3S2
Molecular Weight
497.46
References & Citations
[1]A Novel STAT3 Inhibitor Has Potent Activity in Preclinical Models of Acute Myeloid Leukemia That Incorporate the Stromal Environment. Blood.2015 Dec 3.126 (23) : 569.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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