MM-589

CAT: 0804-HY-100869Size: 1 EachDry Ice: NoHazardous: No

CAT#:0804-HY-100869Size:1 Each

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Description

MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM[1].

CAS Number

[2097887-20-0]

UNSPSC

12352005

Target

WDR5

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/MM-589.html

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(NCC[C@](NC(C(C)C)=O)(C)C1=O)[C@H](NC([C@@H](NC([C@H](CCCNC(NC)=N)N1)=O)CC)=O)C2=CC=CC=C2

Molecular Formula

C28H44N8O5

Molecular Weight

572.70

References & Citations

[1]Karatas H, et al. Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5) -Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J Med Chem. 2017 Jun 22;60 (12) :4818-4839.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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MBS3844885-01	MM-589
T12091L-01	MM-589 TFA
A20440-5	MM-589 5mg
A20440-25	MM-589 25mg
A20440-1	MM-589 1mg
A20440-10	MM-589 10mg
A20440-50	MM-589 50mg
A20440-100	MM-589 100mg
A21892-10	MM-589 TFA 10mg
A21892-25	MM-589 TFA 25mg

MM-589

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