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VinclozolinM2-2204

CAT: 0804-HY-161741-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-161741-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VinclozolinM2-2204 is a androgen receptor (AR) AUTOTAC degrader, with an DC50 of 200 nM in LNCaP prostate cancer cells. VinclozolinM2-2204 induces the formation of AR+LC3+ autophagic membranes. VinclozolinM2-2204 can be used for the research of cancer[1]. (Pink: AR inhibitor ; Black: linker (HY-128833) ; Blue: CRBN Ligand (HY-168293) )
UNSPSC
12352005
Target
Androgen Receptor; AUTOTACs
Type
Reference compound
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vinclozolinm2-2204.html
Purity
98.00
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O[C@H](CNCCOCCOCCNC(N(C1=CC(Cl)=CC(Cl)=C1)C(C(C)(O)C=C)=O)=O)COC2=CC(OCCC3=CC=CC=C3)=C(OCCC4=CC=CC=C4)C=C2
Molecular Formula
C43H51Cl2N3O9
Molecular Weight
824.79
References & Citations
[1]Ji CH, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13 (1) :904. doi: 10.1038/s41467-022-28520-4. Erratum in: Nat Commun. 2022 Apr 12;13 (1) :2108.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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