HCI-2184

CAT: 0804-HY-117398Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-117398Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HCI-2184 is a Nek2 inhibitor with an IC50 of 39.90 nM. HCI-2184 significantly increases the effectiveness of Bortezomib (HY-10227) in inhibiting proteasome activity[1].
CAS Number
[1341200-61-0]
UNSPSC
12352005
Target
NEKs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hci-2184.html
Smiles
O=S(C1=C(NC2=NC(NC3=CC=C(N4CCN(CC4)C)C=C3)=NC=C2Cl)C=CC=C1)(N(C)C)=O
Molecular Formula
C23H28ClN7O2S
Molecular Weight
502.03
References & Citations
[1]Meng L, et al. Inhibition of Nek2 by small molecules affects proteasome activity. Biomed Res Int. 2014;2014:273180.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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