AM-9022

• Description:

  AM-9022 is an orally active, potent, selective KIF18A inhibitor that can be used for research on cancer[1].

• UNSPSC:

  12352005

• Target:

  Kinesin; Microtubule/Tubulin

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/am-9022.html

• Purity:

  99.48

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=CC=C(NS([C@H](C)CO)(=O)=O)C=C1N2CCC3(CC3)CC2)NC4=CC(C)=NC(N5CCC(F)(F)CC5)=N4

• Molecular Formula:

  C27H36F2N6O4S

• Molecular Weight:

  578.67

• References & Citations:

  [1]Payton M, et al. Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers. Nat Cancer. 2023 Dec 27.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2446872-46-2]