Anti-FoxP3 Purified

CAT: 0793-30-2739-0.1Size: 0.1 mgDry Ice: NoHazardous: No

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CAT#:0793-30-2739-0.1Size:0.1 mg

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Description

FoxP3 (forkhead box protein 3), a highly conserved forkhead/winged-helix transcription factor, plays a crucial role in maintaining immune homeostasis by governing the development and function of regulatory T cells. It is constitutively expressed at high level in CD25+ CD4+ Treg cells and at low level in a CD25- CD4+ Treg cell subset. Defects in gene encoding FoxP3 protein cause the scurfy phenotype in mice, and in human the IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome.Specificity :The mouse monoclonal antibody 3G3 recognizes N-terminal region of FoxP3, a 47-55 kDa transcription factor (intracellular antigen), which is the master regulator in the development and function of regulatory T cells.

Product Name Alternative

Forkhead box P3 Scurfin, JM2, AIID, IPEX, PIDX, XPID, DIETER

Gene Name

FOXP3

Gene ID

50943

UniProt

Q9BZS1

Reactivity

Human, Mouse

Immunogen

Full-length His-tagged recombinant murine FoxP3

Target Antigen

FoxP3

Clonality

Monoclonal

Clone

3G3

Applications

FACS, WB

Purification

Purified by protein-A affinity chromatography.

Format

Purified

Components

Concentration: 1 mg/mLStorage Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage Conditions

Store at 2-8°C. Do not freeze.

Applications Notes

Western blotting: Recommended dilution: 2 μg/mL. Flow cytometry: Recommended dilution: 1-4 μg/mL. Intracellular staining.

UniProtKB · Q9BZS1

Forkhead box protein P3

FOXP3_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9BZS1
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: FOXP3
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: A5HJT1, B7ZLG0, B9UN80, O60827, Q14DD8, Q4ZH51

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-bindingRepressor

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Disease

Diabetes mellitusDisease variant

Ligand

Metal-bindingZinc

Biological process

TranscriptionTranscription regulation

Domain

Zinc-finger

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Alternative Products

Catalog	Name
11-601-C100	Anti-FoxP3 Purified
E16FHUFOX-100U	Purified anti-human FOXP3
M00011-1	Anti-FoxP3 Purified Monoclonal Antibody
GT02601	Purified anti-mouse FOXP3 Recombinant
E-AB-F1238A-01	Purified Anti-Mouse Foxp3 Antibody[3G3]
DL20224F-01	Purified Anti-Human FOXP3 Monoclonal Antibody
GT09779	Purified anti-mouse/rat/human FOXP3
AN009460P-01	Purified Anti-Mouse FOXP3 Antibody[MF-14]
MBS8506024-01	Mouse anti-Human FOXP3 Monoclonal Antibody, Purified
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