Anti-p63 Purified

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CAT#:0793-30-2724-0.1Size:0.1 mg

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Description

The p53 family of proteins includes three members, p53, p63, and p73. The protein p63 is encoded by TP63 gene, which gives rise to protein isoforms with different properties and functions due to the presence (TAp63) or absence (deltaNp63) of an N-terminal transactivation domain. Immunohistochemistry of p63 has a clinical relevance for certain tumor types, but investigations have been hampered by a lack of well characterized antibodies that are specific for p63 and do not cross-react with the related p53 and p73 proteins. Specificity :The mouse monoclonal antibody PANp63-6.1 recognizes both TAp63, and deltaNp63 form of p63. The target epitope PSHLIR is located within amino acids 261-266 of TAp63, and 167-172 of deltaNp63.

Product Name Alternative

Tumor protein p63 TAp63 + deltaNp63, AIS, KET, LMS, NBP, RHS, EEC3, OFC8, SHFM4

Gene Name

TP63

Gene ID

8626

UniProt

Q9H3D4

Reactivity

Mouse

Immunogen

Recombinant full length human p63

Target Antigen

P63

Clonality

Monoclonal

Clone

PANp63-6.1

Applications

Purification

Purified by protein-A affinity chromatography.

Format

Purified

Components

Concentration: 1 mg/mLStorage Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage Conditions

Store at 2-8°C. Do not freeze.

Applications Notes

Western blotting: Recommended dilution: 1 μg/mL

UniProtKB · Q9H3D4

Tumor protein 63

P63_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9H3D4
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: TP63
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: p63
EC number: —
Processing: —
Secondary accessions: O75080, O75195, O75922, O76078, Q6VEG2, Q6VEG3, Q6VEG4, Q6VFJ1, Q6VFJ2, Q6VFJ3, Q6VH20, Q7LDI3, Q7LDI4, Q7LDI5, Q96KR0, Q9H3D2, Q9H3D3, Q9H3P8, Q9NPH7, Q9P1B4, Q9P1B5, Q9P1B6, Q9P1B7, Q9UBV9, Q9UE10, Q9UP26, Q9UP27, Q9UP28, Q9UP74

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDevelopmental proteinDNA-binding

Coding sequence diversity

Alternative promoter usageAlternative splicing

Biological process

ApoptosisNotch signaling pathwayTranscriptionTranscription regulation

Disease

Disease variantEctodermal dysplasiaPremature ovarian failure

PTM

Isopeptide bondUbl conjugation

Ligand

Metal-bindingZinc

Cellular component

Nucleus

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