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Anti-PPM1D Purified

CAT: 0793-30-2720-0.1Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0793-30-2720-0.1Size:0.1 mg
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Description
PPM1D is a Mg2+/Mn2+ dependent protein phosphatase 1D with inducible expression in response to various types of environmental stress. This expression is p53-dependent, and subsequently PPM1D negatively regulates the p53-mediated transcription, thus it suppresses the apoptosis. PPM1D contributes to development of carcinomas, and seems to be a promissing therapeutic target. Amplification of PPM1D is associated with breast cancer. Specificity :The mouse monoclonal antibody 7E11/C5 recognizes an epitope within the sequence FTNEDELYNLLTDSP of PPM1D, a protein phosphatase, which contributes to development of some carcinomas.
Product Name Alternative
Protein phosphatase, Mg2+/Mn2+ dependent 1D WIP1, Protein phosphatase 1D, JDVS, WIP1, IDDGIP
Gene Name
PPM1D
Gene ID
8493
UniProt
O15297
Reactivity
Mouse
Immunogen
Purified human PPM1D
Target Antigen
PPM1D
Clonality
Monoclonal
Clone
7E11/C5
Applications
WB
Purification
Purified by protein-A affinity chromatography.
Format
Purified
Components
Concentration: 1 mg/mLStorage Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage Conditions
Store at 2-8°C. Do not freeze.
Applications Notes
Western blotting: Recommended dilution: 1-2 μg/mL.

UniProtKB · O15297

Protein phosphatase 1D

PPM1D_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15297
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PPM1D
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.3.16
Processing
—
Secondary accessions
Q53XP4, Q6P991, Q8IVR6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Autism spectrum disorderDisease variantIntellectual disability

Biological process

Cell cycle

Cellular component

CytoplasmNucleus

Molecular function

HydrolaseProtein phosphatase

Ligand

MagnesiumManganeseMetal-binding

PTM

Phosphoprotein

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