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Anti-CD325 Purified

CAT: 0793-30-2703-0.1Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0793-30-2703-0.1Size:0.1 mg
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Description
Specificity : The mouse monoclonal antibody 8C11 recognizes an extracellular epitope of CD325 (N-cadherin), a transmembrane protein associated with actin cytoskeleton system, which is expressed mainly by neurons, osteoblasts, endothelial cells, and stem cells. CD325 (N-cadherin) is a type I transmembrane protein, which forms a complex with catenins, that is linked to the actin cytoskeleton. This complex is important in synapses and for functional plasticity of neurons, and is also essential for embryonic development. Decreased CD325 cleavage caused by mutations in presenilin 1 is associated with Alzheimer ́s disease. Besides nervous system, CD325 is expressed on the surface of malignant T cells, and increases their adhesion to epithelia, as well as their ability to invade and metastasize to inflammatory sites.
Product Name Alternative
N-Cadherin, cadherin 2, CDHM, CDH2
Gene ID
1000
UniProt
P19022
Host
Mouse
Reactivity
Mouse, Human
Immunogen
Bacterially expressed extracellular domain of human CD325
Target Antigen
CD325
Clone
8C11
Applications
IP, ICC, IHC, FACS, WB
Purification
Purified by protein-A affinity chromatography.
Format
Purified
Components
1 mg/mL Formulation : Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage Conditions
Store at 2-8°C. Do not freeze.
Applications Notes
Flow cytometry: Recommended dilution: 1-4 μg/ml.
Isotype
Mouse IgG1 kappa

UniProtKB · P19022

Cadherin-2

CADH2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P19022
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CDH2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A8MWK3, B0YIY6, Q14923, Q8N173
Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-binding

Disease

CardiomyopathyDisease variantIntellectual disability

Biological process

Cell adhesion

Cellular component

Cell junctionCell membraneCell projectionMembrane

PTM

Cleavage on pair of basic residuesGlycoproteinPhosphoprotein

Technical term

Proteomics identificationReference proteome

Domain

RepeatSignalTransmembraneTransmembrane helix

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