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Mouse anti Human Muc1

CAT: 0579-X1603MSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0579-X1603MSize:100 µg
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Background
Muc1 is a heavily O-glycosylated transmembrane protein expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed in >90% breast carcinomas and metastases. In normal mammary gland it is expressed in apical surface of glandular epithelium. In breast cancer Muc1 is overexpressed; is underglycosylated and the apical localization is lost. Muc1 is transcribed as a larger precursor which is cleaved to form a larger mucin like subunit (265-400kDa) and a smaller subunit (14-28kDa) noncovalently associated with each other. Transgenic Muc1 has been shown to associate with all four erbB receptors and localize with erbB1 (EGFR) in lactating glands1. Muc1 can act as a ligand for ICAM-1 on HUVEC cells; it can bind -catenin, GSK3 and it associates with Grb2-SOS upon phosphorylation.
CAS Number
9007-83-4
Synonyms
Episialin
UniProt
P15941
Host
Mouse
Species Reactivity
Human
Isotype
IgG1
Clone
VU-3C6
Conjugation
Unconjugated
Type
Monoclonal Antibody
Applications
IHC (frozen and paraffin), ELISA, WB
Field of Research
Signal Transduction
Purification Method
Protein A/G Chromatography
Assay Principle
The antibody reacts with the extracellular 12-mer GVTSAPDTRPAP epitope of the MUC-1 tandem repeat.Antibody can be used for immunohistochemistry on frozen and paraffin embedded tissues and ELISA. Optimal concentration should be evaluated by serial dilutions.
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
Provided as solution in phosphate buffered saline with 0,08% sodium azide
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
References & Citations
1. Schol, D.J. et al., Epitope fingerprinting using overlapping 20-mer peptides of the MUC 1 tandem repeat sequence. Tumor Biol. Suppl. 1998: 19, 35-45. 2. Price, M.R. et al., Analysis of 56 monoclonal antibodies against the MUC1 mucin.Tumor Biol. Suppl. 1998: 19, 1-20. 3. Cao, Y. et al., Immunohistochemical characterization of a panel of 56 anti bodies with normal Human small intestine, colon, and breast  tissues. Tumor Biol. Suppl. 1998: 19, 88-99
Shipping Conditions
Ambient Temperature, freeze upon arrival
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
WB

UniProtKB · P15941

Mucin-1

MUC1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P15941
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MUC1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MUC-1
EC number
—
Processing
Precursor
Secondary accessions
A5YRV1, A6ZID9, A6ZIE0, B1AVQ8, B1AVR0, B6ECA1, E7ESE5, E7EUG9, P13931, P15942, P17626, Q0VAP5, Q0VAP6, Q14128, Q14876, Q16437, Q16442, Q16615, Q6S4Y3, Q7Z547, Q7Z548, Q7Z550, Q7Z552, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

PTM

Autocatalytic cleavageDisulfide bondGlycoproteinLipoproteinPalmitatePhosphoprotein

Cellular component

Cell membraneCytoplasmMembraneNucleusSecreted

Domain

RepeatSignalTransmembraneTransmembrane helix

Disease

Tumor suppressor

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