WH-4-023

CAT: 0804-HY-12299-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12299-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WH-4-023 is a potent and selective dual Lck/Src inhibitor with IC50 of 2 nM/6 nM for Lck and Src kinase respectively; little inhibition on p38α and KDR.
CAS Number
[837422-57-8]
Product Name Alternative
Dual LCK/SRC inhibitor
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Src
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/WH-4-023.html
Purity
99.87
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(OC1=C(C)C=CC=C1C)N(C2=CC=C(OC)C=C2OC)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=NC=C3
Molecular Formula
C32H36N6O4
Molecular Weight
568.67
Precautions
H302, H315, H319, H335
References & Citations
[1]Martin MW, et al. Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity. J Med Chem. 2006 Aug 10;49 (16) :4981-91.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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