WH-15

• Description:

  WH-15 is a fluorogenic PLC reporter with Km value of 49; 30, 86.1 µM for PLC-γ1, PLC-δ1, PLC-β2, respectively. WH-15 can be cleaved in a cascade reaction to generate fluorescent 6-aminoquinoline. WH-15 can be used to respond to imaging PLC activity in live cells (Ex/Em = ~344/530 nm) [1].

• UNSPSC:

  12171500

• Target:

  Phospholipase

• Type:

  Dye Reagents

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/wh-15.html

• Purity:

  99.51

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  O[C@@H]1[C@H](OP(O)(OC2=CC=C(COC(NC3=CC=C4N=CC=CC4=C3)=O)C=C2OCCCCCCCC)=O)[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H]1O

• Molecular Formula:

  C31H43N2O18P3

• Molecular Weight:

  824.60

• References & Citations:

  [1]Huang W, et al. A fluorogenic, small molecule reporter for mammalian phospholipase C isozymes. ACS Chem Biol. 2011 Mar 18;6 (3) :223-8.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category:

  Dye Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  [1264748-47-1]