DA-023

• Description:

  DA-023 (Compound 4) is a selective positive allosteric modulator (PAM) of EAAT2 with an EC50 value of 1 nM[1].

• UNSPSC:

  12352005

• Target:

  EAAT

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/da-023.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CN1CCN(C(C2=NN=NN2CCC3=CC=CC=C3)C4=CC=CN=C4)CC1

• Molecular Formula:

  C20H25N7

• Molecular Weight:

  363.46

• References & Citations:

  [1]Fontana ACK, et al. Synthesis and Structure-Activity Relationships for Glutamate Transporter Allosteric Modulators. J Med Chem. 2024;67 (8) :6119-6143.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2585643-97-4]