ICRF-196

• UNSPSC Description:

  ICRF-196 is an racemic mixture of the (S,S)- and (R,R)-isomers of ICRF-193 (HY-118590). ICRF-193 is an TopoII inhibitor. ICRF-196 can be used for the research of cancer[1].

• Target Antigen:

  Topoisomerase

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/icrf-196.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(N(C1)CC(NC1=O)=O)C(N(C2)CC(NC2=O)=O)C

• Molecular Weight:

  282.30

• References & Citations:

  [1]Snapka RM,et al. Inhibition of topoisomerase II by ICRF-193, the meso isomer of 2,3-bis(2,6-dioxopiperazin-4-yl)butane. Critical dependence on 2,3-butanediyl linker absolute configuration. Biochem Pharmacol. 1996;52(4):543-549.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  21416-68-2