PD 124816

CAT: 0804-HY-W780694Size: 1 EachDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-W780694Size:1 Each

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

PD 124816 is an orally active fluoroquinolone antibiotic. PD 124816 exerts broad-spectrum antibacterial effects by inhibiting DNA gyrase (topoisomerase IV), and it has no cross-resistance with commonly used antibiotics. PD 124816 is effective against both Gram-positive and Gram-negative bacteria (MIC₉₀ ≤ 0.06 μg/mL), and the MIC₉₀ for anaerobic bacteria (Peptostreptococcus fragi) is 1 μg/mL. PD 124816 exhibits complete bactericidal activity in a mouse model of Mycobacterium leprae infection. PD 124816 can be used for studying mixed infections and infections caused by drug-resistant bacteria[1][2].

CAS Number

112654-98-5

UNSPSC

12352005

Target

Antibiotic; Bacterial; DNA/RNA Synthesis; Topoisomerase

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Infection

Smiles

FC1=C(C2=C(C(F)=C1N3CC(CC3)N)N)N(C=C(C2=O)C(O)=O)C4CC4

Molecular Formula

C17H18F2N4O3

Molecular Weight

364.35

References & Citations

[1]Cohen MA, et al. In vitro antibacterial activities of the fluoroquinolones PD 117596, PD 124816, and PD 127391. Diagn Microbiol Infect Dis. 1991 May-Jun;14 (3) :245-58. |[2]Gelber RH, et al. Activities of various quinolone antibiotics against Mycobacterium leprae in infected mice. Antimicrob Agents Chemother. 1992 Nov;36 (11) :2544-7.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Quinolone

Related Products

Catalog	Name
HY-144649	PD-1/PD-L1-IN-24
HY-132202-01	PD-1/PD-L1-IN-10
HY-144442	PD-1/PD-L1-IN-15
HY-129172A	PD-1/PD-L1-IN 5
HY-145770	PD-1/PD-L1-IN-19
HY-179180	PD-1/PD-L1-IN-59
HY-175702	PD-1/PD-L1-IN-57
HY-144447	PD-1/PD-L1-IN-17
HY-169190	PD-1/PD-L1-IN-53
HY-144746	PD-1/PD-L1-IN-26

PD 124816

Related Products

Popular Products