Oxaprozin-d10

CAT: 0804-HY-W709448Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-W709448Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Oxaprozin-d10 (Oxaprozinum-d10; Wy21743-d10) is the deuterium labeled Oxaprozin (HY-B0808) . Oxaprozin is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties[1][2].
Product Name Alternative
Oxaprozinum-d10; Wy21743-d10
UNSPSC
12352005
Target
Akt; Apoptosis; COX; IKK; Isotope-Labeled Compounds; NF-κB
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB; Others; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
[2H]C1=C(C([2H])=C(C([2H])=C1C2=C(OC(CCC(O)=O)=N2)C3=C(C([2H])=C(C([2H])=C3[2H])[2H])[2H])[2H])[2H]
Molecular Formula
C18H5D10NO3
Molecular Weight
303.38
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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