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Oxaprozin (potassium)

CAT: 0804-HY-B0808ASize: 1 EachDry Ice: NoHazardous: No
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Description
Oxaprozin potassium is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin potassium also inhibits the activation of NF-κB. Oxaprozin potassium induces cell apoptosis. Oxaprozin potassium shows anti-inflammatory activity. Oxaprozin potassium-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties[1][2].
CAS Number
174064-08-5
Product Name Alternative
Oxaprozinum (potassium) ; Wy21743 (potassium)
UNSPSC
12352005
Target
Akt; Apoptosis; COX; IKK; NF-κB
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/oxaprozin-potassium.html
Solubility
10 mM in DMSO
Smiles
O=C(O[K])CCC1=NC(C2=CC=CC=C2)=C(C3=CC=CC=C3)O1
Molecular Formula
C18H14KNO3
Molecular Weight
331.41
References & Citations
[1]Ottonello L, et al. Delayed apoptosis of human monocytes exposed to immune complexes is reversed byoxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway. Br J Pharmacol. 2009 May;157 (2) :294-306.|[2]Montecucco F, et al. Oxaprozin-induced apoptosis on CD40 ligand-treated human primary monocytes is associated with the modulation of defined intracellular pathways. J Biomed Biotechnol. 2009;2009:478785.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
COX-1; COX-2; IKK; NF-κB

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