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Oxaprozin (Standard)

CAT: 0804-HY-B0808R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0808R-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Oxaprozin (Standard) is the analytical standard of Oxaprozin. This product is intended for research and analytical applications. Oxaprozin is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties[1][2].
CAS Number
21256-18-8
Product Name Alternative
Oxaprozinum (Standard) ; Wy21743 (Standard)
UNSPSC
12352005
Hazard Statement
H302
Target
Akt; Apoptosis; COX; IKK; NF-κB; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB; Others; PI3K/Akt/mTOR
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/oxaprozin-standard.html
Smiles
O=C(O)CCC1=NC(C2=CC=CC=C2)=C(C3=CC=CC=C3)O1
Molecular Formula
C18H15NO3
Molecular Weight
293.32
Precautions
P264-P270-P330-P501
References & Citations
[1]Ottonello L, et al. Delayed apoptosis of human monocytes exposed to immune complexes is reversed byoxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway. Br J Pharmacol. 2009 May;157 (2) :294-306.|[2]Montecucco F, et al. Oxaprozin-induced apoptosis on CD40 ligand-treated human primary monocytes is associated with the modulation of defined intracellular pathways. J Biomed Biotechnol. 2009;2009:478785.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
Launched

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