Succinate (calcium)

• Description:

  Succinate calcium is a key intermediate product of the citric acid cycle (tricarboxylic acid cycle) . Succinate calcium can act as a specific ligand for the G protein-coupled receptor GPR91. Succinate calcium can increase the amplitude of calcium transient in cardiac muscle cells and accelerate the decay rate of calcium transient. Succinate calcium can induce myocardial apoptosis[1].

• UNSPSC:

  12352211

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Apoptosis; Orphan GPCR

• Related Pathways:

  Apoptosis; GPCR/G Protein

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Cardiovascular Disease

• Smiles:

  O=C ([O-]) CCC ([O-]) =O.[Ca+2]

• Molecular Formula:

  C4H4CaO4

• Molecular Weight:

  156.15

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Aguiar C J, et al. Gomes E R M, et al. Succinate modulates Ca2+ transient and cardiomyocyte viability through PKA-dependent pathway[J]. Cell calcium, 2010, 47 (1) : 37-46.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  140-99-8