TMPO

• Description :

  TMPO (3,3,5,5-Tetramethyl-1-pyrroline 1-oxide) is a spin trap targeting free radicals. TMPO is capable of scavenging superoxide, hydroxyl radicals and inhibits thymocyte apoptosis with EC50 values of 19.1 mM (MPS-induced) to 30.7 mM (Etoposide-induced) for inhibiting DNA fragmentation. TMPO reacts with intracellular free radicals to form stable nitroxide radical products, reducing oxidative stress (e.g., decreasing peroxide levels, maintaining glutathione content) and blocking oxidative events in the apoptotic pathway. TMPO is promising for research of apoptosis in immune cells like thymocytes[1][2].

• Product Name Alternative :

  3,3,5,5-Tetramethyl-1-pyrroline 1-oxide

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319

• Target :

  Apoptosis; Reactive Oxygen Species (ROS)

• Related Pathways :

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Field of Research :

  Inflammation/Immunology

• Smiles :

  CC1(C)CC(C)(C)[N+](=C1)[O-]

• Molecular Formula :

  C8H15NO

• Molecular Weight :

  141.21

• Precautions :

  P264-P280-P302+P352-P305+P351+P338-P362+P364

• References & Citations :

  [1]Buettner GR, et al. The spin trapping of superoxide with M4PO (3,3,5,5-tetramethylpyrroline-N-oxide) . Free Radic Biol Med. 1990;8 (1) :57-60.|[2]Slater AF, et al. Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis. Biochem J. 1995 Mar 15;306 (Pt 3) (Pt 3) :771-8.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [10135-38-3]