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TMPO

CAT: 0804-HY-W271506Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W271506Size:1 Each
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Description
TMPO (3,3,5,5-Tetramethyl-1-pyrroline 1-oxide) is a spin trap targeting free radicals. TMPO is capable of scavenging superoxide, hydroxyl radicals and inhibits thymocyte apoptosis with EC50 values of 19.1 mM (MPS-induced) to 30.7 mM (Etoposide-induced) for inhibiting DNA fragmentation. TMPO reacts with intracellular free radicals to form stable nitroxide radical products, reducing oxidative stress (e.g., decreasing peroxide levels, maintaining glutathione content) and blocking oxidative events in the apoptotic pathway. TMPO is promising for research of apoptosis in immune cells like thymocytes[1][2].
CAS Number
10135-38-3
Product Name Alternative
3,3,5,5-Tetramethyl-1-pyrroline 1-oxide
UNSPSC
12352005
Hazard Statement
H315-H319
Target
Apoptosis; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Inflammation/Immunology
Smiles
CC1(C)CC(C)(C)[N+](=C1)[O-]
Molecular Formula
C8H15NO
Molecular Weight
141.21
Precautions
P264-P280-P302+P352-P305+P351+P338-P362+P364
References & Citations
[1]Buettner GR, et al. The spin trapping of superoxide with M4PO (3,3,5,5-tetramethylpyrroline-N-oxide) . Free Radic Biol Med. 1990;8 (1) :57-60.|[2]Slater AF, et al. Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis. Biochem J. 1995 Mar 15;306 (Pt 3) (Pt 3) :771-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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