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TMP1

CAT: 0804-HY-175344Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175344Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TMP1 is an orally active bispecific inhibitor of M pro (IC50 = 312.5 nM) /TMPRSS2 (IC50 = 1.28 μM, KD = 10.10 μM). TMP1 exhibits broad protection against different SARS-CoV-2 variants in vitro. TMP1 cross-protects against highly pathogenic coronaviruses (SARS-CoV-1, SARS-CoV-2, and MERS-CoV) in vivo and effectively blocks the transmission of SARS-CoV-2. TMP1 can inhibit infection by SARS-CoV-2 escape mutants that are resistant to Nivolumab. TMP1 can be used in coronavirus research[1].
UNSPSC
12352005
Target
SARS-CoV; Ser/Thr Protease; Virus Protease
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Smiles
O=C(C([C@H](NC([C@@H]1C[C@H](CN1C([C@H](C2CCCCC2)NC(C3CCC(F)(CC3)F)=O)=O)F)=O)CC4=CC=CC=C4)=O)NCC5=NC=C(C=C5)Cl
Molecular Formula
C36H43ClF3N5O5
Molecular Weight
718.21
References & Citations
[1]Chu H, et al. An orally available Mpro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo. Res Sq [Preprint]. 2024 Nov 21:rs.3.rs-5454588. doi: 10.21203/rs.3.rs-5454588/v1. Update in: Nat Commun. 2025 Jul 16;16 (1) :6541.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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