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TMPA

CAT: 0804-HY-18555-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18555-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TMPA is a high-affinity Nur77 antagonist that binds to Nur77 leading to the release and shuttling of LKB1 in the cytoplasm to activate AMPKα. TMPA effectively lowers blood glucose and attenuates insulin resistance in type II db/db, high-fat diet and streptozotocin-induced diabetic mice. TMPA reduces RICD (restimulation-induced cell death) in human T cells, can also be used in studies of cancer and T-cell apoptosis dysregulation[1][2].
CAS Number
1258275-73-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
AMPK; Nuclear Hormone Receptor 4A/NR4A
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/TMPA.html
Purity
98.40
Solubility
DMSO : ≥ 100 mg/mL
Smiles
COC1=C(CC(OCC)=O)C(C(CCCCCCC)=O)=CC(OC)=C1OC
Molecular Formula
C21H32O6
Molecular Weight
380.48
Precautions
H302, H315, H319
References & Citations
[1]Zhan YY, et al. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nat Chem Biol. 2012 Nov;8 (11) :897-904. |[2]Recher, et al. Modulation of T-cell apoptosis by small molecule compounds targeting the nuclear orphan receptor Nur 77. (2018) .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nur77/NR4A1

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