XMU-MP-8

• Description:

  XMU-MP-8 (SKPer1) is a potent molecular glue degrader that targets the oncoprotein SKP2. XMU-MP-8 simultaneously binds to the F-box domain of SKP2 (Kd ≈ 36 μM) and the N-terminal TPR domain of the E3 ligase STUB1 (Kd ≈ 2.5 μM), forming a stable SKP2-SKPer1-STUB1 ternary complex (Kd ≈ 8.9 nM) that induces SKP2 ubiquitination and proteasomal degradation. XMU-MP-8 selectively eliminates SKP2-expressing cancer cells. XMU-MP-8 exhibits substantial tumour suppression with good safety profiles in vivo. XMU-MP-8 can be used for cancer research, such as non-small cell lung adenocarcinoma (NSCLC) and prostatic adenocarcinoma[1].

• Product Name Alternative:

  SKPer1

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  E1/E2/E3 Enzyme; Molecular Glues

• Related Pathways:

  Metabolic Enzyme/Protease; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Purity:

  99.23

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  CN1N=CC2=C(NCC3=CC=CN=C3)N=C(C4=CC=CC(NC(NC5=CC=CC(C(F)(F)F)=C5)=S)=C4)N=C21

• Molecular Formula:

  C26H21F3N8S

• Molecular Weight:

  534.56

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Chu Y, et al. A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2. Nat Biotechnol. 2025 Sep 10.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2271314-01-1