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XMU-MP-8

CAT: 0013-GTR19275170-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19275170-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XMU-MP-8 (SKPer1) is a potent molecular glue degrader that targets the oncogenic protein SKP2. It interacts with the F-box domain of SKP2 (Kd≈ 36 μM) and the N-terminal TPR domain of the E3 ligase STUB1 (Kd≈ 2.5 μM), leading to the formation of a stable SKP2-SKPer1-STUB1 ternary complex (Kd≈ 8.9 nM) . This interaction triggers the ubiquitination and proteasomal degradation of SKP2. XMU-MP-8 selectively eradicates cancer cells expressing SKP2 and exhibits notable tumor-suppressive effects in vivo along with a favorable safety profile. It is applicable in research on cancers such as non-small cell lung adenocarcinoma (NSCLC) and prostate adenocarcinoma.
CAS Number
2271314-01-1
Smiles
FC (F) (F) C=1C=CC=C (C1) NC (=S) NC2=CC=CC (=C2) C=3N=C (NCC=4C=NC=CC4) C=5C=NN (C5N3) C
Molecular Formula
C26H21F3N8S
Molecular Weight
534.57
Storage Conditions
-20°C
Notes
For research use only.

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