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GSK3β-IN-3

CAT: 0804-HY-W098905Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W098905Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK3β-IN-3 is an ATP-competitive GSK-3β inhibitor (IC50 = 0.90 μM) . GSK3β-IN-3 can reduce the phosphorylation level of tau protein in the BR5706 strain and reduce the deposition of Aβ aggregates in the CL2006 strain, and can be used to research Alzheimer's disease (AD) [1].
CAS Number
301359-45-5
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Amyloid-β; Cytochrome P450; GSK-3; Tau Protein
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CCOC(C1=C(NC(NC1C2=CC=CC=C2Cl)=S)C)=O
Molecular Formula
C14H15ClN2O2S
Molecular Weight
310.80
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Sukanya S, et al. Exploring 2-Thioxo-1,2,3,4-tetrahydropyrimidines as Dual Acting GSK-3β/Aβ Aggregation Inhibitors: Implications for Alzheimer's Disease Treatment. Drug Dev Res. 2025 Jun;86 (4) :e70112.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Isoform
GSK-3β

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