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GSK3-IN-1

CAT: 0804-HY-Q48328-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-Q48328-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK3-IN-1 (compound 11) is a GSK-3 inhibitor with an IC50 value of 12 μM. GSK3-IN-1 can be used in the research of diabetes[1].
CAS Number
478482-74-5
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gsk3-in-1.html
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 52°C)
Smiles
ClC1=C(CSC2=NN=C(C3=CC=NC=C3)O2)C=CC=C1
Molecular Formula
C14H10ClN3OS
Molecular Weight
303.77
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Lars Naerum, et al. Scaffold hopping and optimization towards libraries of glycogen synthase kinase-3 inhibitors. Bioorg Med Chem Lett. 2002 Jun 3;12 (11) :1525-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Dedicated for Diverse Library
Clinical Information
No Development Reported

Chemical Information

2-Chlorobenzyl 5-(4-pyridinyl)-1,3,4-oxadiazol-2-yl sulfide
CAS Number478482-74-5
PubChem CID851256
IUPAC Name2-[(2-chlorophenyl)methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole
Molecular FormulaC14H10ClN3OS
Molecular Weight303.8
XLogP3.3
Topological Polar Surface Area77.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count20
Formal Charge0
Complexity304
SMILES
C1=CC=C(C(=C1)CSC2=NN=C(O2)C3=CC=NC=C3)Cl
InChI
InChI=1S/C14H10ClN3OS/c15-12-4-2-1-3-11(12)9-20-14-18-17-13(19-14)10-5-7-16-8-6-10/h1-8H,9H2
InChIKey
UMPGWHXDJJYISZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-Chlorobenzyl 5-(4-pyridinyl)-1,3,4-oxadiazol-2-yl sulfide
CAS: 478482-74-5
CID: 851256
Formula: C14H10ClN3OS
MW: 303.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight303.8
XLogP33.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass303.0233108
Monoisotopic Mass303.0233108
Topological Polar Surface Area77.1 Ų
Heavy Atom Count20
Formal Charge0
Complexity304
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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